31 August 2012
Last updated at 04:22 GMT
Clint Eastwood meanwhile caused a stir, delivering rambling remarks to an empty chair he said represented Barack Obama.
Mr Romney will challenge the Democratic president in November's election.
Glowing tributes "I wish President Obama had succeeded because I want America to succeed," the former Massachusetts governor said.
"But his promises gave way to disappointment and division. This isn't something we have to accept."
The presidential nominee recounted details of his Mormon upbringing, with details about his family life and his parents' loving marriage.
Mr Romney talked about his own experiences as a father, apparently becoming emotional as he talked about the times when he and his wife Ann would wake up to find "a pile of kids asleep in our room".
But he levelled a barrage of attacks at President Obama: "The time has come to turn the page. Today the time has come for us to put the disappointments of the last four years behind us. To put aside the divisiveness and the recriminations.
"Now is the time to restore the promise of America," he added.
'No apology' Mr Romney vowed to create 12 million American jobs over the next four years and turn around an economy saddled with an 8.3% unemployment rate.
"I will begin my presidency with a jobs tour. President Obama began his presidency with an apology tour," he said.
He added that the president had not done enough to support Israel, while being too lenient with Iran.
Mr Romney also brought the crowd to its feet when he pledged to repeal Mr Obama's signature healthcare bill.
He continued: "President Obama promised to begin to slow the rise of the oceans and heal the planet. My promise... is to help you and your family."
Thursday evening's festivities culminated with the entire Romney family - his wife, five sons and their wives and most of his 18 grandchildren - on stage with him as thousands of balloons were released over the convention floor.
Appearing on stage to pledge his support for Mr Romney, Hollywood star Eastwood raised eyebrows with an off-the-cuff monologue to an imaginary Mr Obama in an empty chair.
Referring to the president, Clint Eastwood told a rapturous audience: "When somebody does not do the job, you've got to let 'em go."
Former Florida Governor Jeb Bush and Mr Romney's former rival presidential candidate, Newt Gingrich, spoke ahead of the nominee's appearance on Thursday evening.
Past business associates - Bain Capital colleague Bob White and Tom Stemberg, the president of stationery giant Staples - praised the candidate.
Mormon church congregants Ted and Pat Oparowski told the convention Mr Romney had befriended their dying son and helped him to write a will.
Florida Senator Marco Rubio introduced the candidate, and a video about Mr Romney's life played just before he took to the stage.
Attack ads Democrats have attacked Mr Romney's record at private equity firm Bain Capital and raised questions about why the candidate has refused to release more than two years of tax returns.
Earlier on Thursday, the Romney campaign released a video hitting back at criticism about his time at Bain Capital.
Analysts say Mr Romney had to use this speech to connect with voters. Low favourability ratings have dogged him throughout his campaign and he trails Mr Obama in likeability.
In an email to donors on Thursday, Mr Romney said: "I commit to you that I will be the president this moment demands."
His speech capped three days of pageantry at the Republican convention, which started a day late because of a tropical storm.
This is Mr Romney's second run for the White House, after an unsuccessful bid in 2008.
On Wednesday, his running mate, Paul Ryan, spoke of his family and childhood while also pledging a "turnaround" for America.
But fact-checkers said there were a number of inaccuracies in Wisconsin congressman Ryan's speech.
Mr Romney's wife, Ann, addressed the convention on Tuesday, making an appeal to female voters, a demographic with which the Republican candidate has had trouble connecting.
Mitt Romney vows to restore America's promise
Mitt Romney: "I wish President Obama had succeeded, because I want America to succeed"
Mitt
Romney has pledged "to restore the promise of America" as he accepted
the Republican presidential nomination at the party's convention in
Florida.
Mr Romney also discussed his stellar business record and
Mormon faith in the prime-time address, the biggest speech of his
career.Clint Eastwood meanwhile caused a stir, delivering rambling remarks to an empty chair he said represented Barack Obama.
Mr Romney will challenge the Democratic president in November's election.
Glowing tributes "I wish President Obama had succeeded because I want America to succeed," the former Massachusetts governor said.
Clint Eastwood: "When somebody does not do the job you've got to let `em go."
The presidential nominee recounted details of his Mormon upbringing, with details about his family life and his parents' loving marriage.
Mr Romney talked about his own experiences as a father, apparently becoming emotional as he talked about the times when he and his wife Ann would wake up to find "a pile of kids asleep in our room".
But he levelled a barrage of attacks at President Obama: "The time has come to turn the page. Today the time has come for us to put the disappointments of the last four years behind us. To put aside the divisiveness and the recriminations.
"Now is the time to restore the promise of America," he added.
'No apology' Mr Romney vowed to create 12 million American jobs over the next four years and turn around an economy saddled with an 8.3% unemployment rate.
"I will begin my presidency with a jobs tour. President Obama began his presidency with an apology tour," he said.
He added that the president had not done enough to support Israel, while being too lenient with Iran.
Mr Romney also brought the crowd to its feet when he pledged to repeal Mr Obama's signature healthcare bill.
He continued: "President Obama promised to begin to slow the rise of the oceans and heal the planet. My promise... is to help you and your family."
Marco Rubio said "hope and change has become divide and conquer"
Thursday evening's festivities culminated with the entire Romney family - his wife, five sons and their wives and most of his 18 grandchildren - on stage with him as thousands of balloons were released over the convention floor.
Appearing on stage to pledge his support for Mr Romney, Hollywood star Eastwood raised eyebrows with an off-the-cuff monologue to an imaginary Mr Obama in an empty chair.
Referring to the president, Clint Eastwood told a rapturous audience: "When somebody does not do the job, you've got to let 'em go."
Former Florida Governor Jeb Bush and Mr Romney's former rival presidential candidate, Newt Gingrich, spoke ahead of the nominee's appearance on Thursday evening.
Past business associates - Bain Capital colleague Bob White and Tom Stemberg, the president of stationery giant Staples - praised the candidate.
Mormon church congregants Ted and Pat Oparowski told the convention Mr Romney had befriended their dying son and helped him to write a will.
Florida Senator Marco Rubio introduced the candidate, and a video about Mr Romney's life played just before he took to the stage.
Attack ads Democrats have attacked Mr Romney's record at private equity firm Bain Capital and raised questions about why the candidate has refused to release more than two years of tax returns.
A top Republican says Mitt Romney must be likeable
Analysts say Mr Romney had to use this speech to connect with voters. Low favourability ratings have dogged him throughout his campaign and he trails Mr Obama in likeability.
In an email to donors on Thursday, Mr Romney said: "I commit to you that I will be the president this moment demands."
His speech capped three days of pageantry at the Republican convention, which started a day late because of a tropical storm.
This is Mr Romney's second run for the White House, after an unsuccessful bid in 2008.
On Wednesday, his running mate, Paul Ryan, spoke of his family and childhood while also pledging a "turnaround" for America.
But fact-checkers said there were a number of inaccuracies in Wisconsin congressman Ryan's speech.
Mr Romney's wife, Ann, addressed the convention on Tuesday, making an appeal to female voters, a demographic with which the Republican candidate has had trouble connecting.
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